Part 1: My Journey
DiagnosisAug '16
TreatmentSep '16
MetastasisJan '17
The CallJan '17
ProtocolJan '17
ClearMay '17
DisclosureSep '17
1 YearApr '18
Sharing2019
5 Years2022
🎗️

My Journey

From terminal diagnosis to understanding why I'm still here

Aug 2016: Rio Olympics. Simone Biles dominates. David Bowie & Prince mourned. Trump vs Clinton heats up.

August 2016
💔

The Diagnosis

Two days before moving to Zurich for a new job, I found out I had small cell lung cancer. A tumor the size of my fist.

My local oncologist: "What you have can't be cured."
I drove to MD Anderson that same day. Their first words: "Joe, we've got this. Think positive."

Sep 2016: Samsung recalls Galaxy Note 7. NFL season kicks off. Hottest August ever recorded.

September 2016
⚡

A Rocky Start

Chemo and radiation began. Then pneumonia. Radiation doubled. My esophagus became "fried bacon." I went 8 weeks without food.

From 200 lbs down to 115 lbs. They wanted a feeding tube. I refused. Then they radiated my brain prophylactically to prevent spread.

Jan 2017: Obama's farewell. Trump inaugurated. Women's March draws millions worldwide.

January 2017
🎄

"Lit Up Like a Christmas Tree"

The PET scan showed cancer had metastasized everywhere. Neck, lung, stomach, liver, bladder, pancreas, tailbone.

<1% survivability. 3 months median life expectancy.
My radiation oncologist — Dr. Stephen Hahn, future FDA Commissioner — said: "We are not giving up."

Jan 2017: Two days after my prognosis. The world continues spinning. Mine had stopped.

January 2017
📞

The Strangest Call of My Life

A veterinarian friend told me about a scientist at Merck Animal Health who cured her own stage 4 brain cancer with a dog dewormer.

She'd been researching cancer in mice. Fenbendazole kept eliminating tumors. When diagnosed herself, she tried it. Six weeks later — all clear.

Late Jan 2017: "What did I have to lose?" I asked myself. The answer was: nothing.

January 2017
🎲

The Leap of Faith

I started fenbendazole along with Theracurmin®

"See why Theracurmin® has been replaced with something better."

JUMP TO THE NEW PROTOCOL →, Vitamin E, and Avemar™. I threw everything but the kitchen sink at it.

No clinical trials. No guarantees. I also stayed on the immunotherapy trial. Multiple fronts. One mission: survive.

May 2017: Macron wins France. "Guardians 2" tops box office. Comey fired. The world buzzes on.

May 2017
🎯

"Are You Kidding Me?"

Three months after lighting up like a Christmas tree, my scan was completely dark. No cancer anywhere. My oncologist was stupefied.

They said I'd never meet my grandchildren. I met my grandson Luke 2.5 weeks before this scan.

Sep 2017: Hurricanes Harvey & Irma devastate. iPhone X announced. "IT" breaks records.

September 2017
🤝

Coming Clean

Six months clear. Trial over. I finally told my oncologist everything. His response: "You little shit, I knew something was up."

He said: "We've known for decades these drugs could work. But they're off-patent. No one will fund the trials."

Apr 2018: Avengers: Infinity War. Royal wedding buzz. Cambridge Analytica scandal breaks.

April 2018
🏆

"Please Leave This Hospital"

Fourth quarter clear. One full year. My doctor said: "We only treat cancer patients here. You need to leave."

He called me "the data outlier of all time." When I asked if he believed my protocol worked, he smiled: "I'll meet you halfway."

2019: Story goes viral in South Korea. Pharmacies sell out. "Game of Thrones" ends. World watches.

2019 and Beyond
📢

Sharing the Story

I started "Get Busy Living." The Facebook group grew to 59,000+ members. Then Dr. Mukhopadhyay — the researcher — reached out.

He had worked at MD Anderson years earlier — researching this exact mechanism. The science was real. It had just been forgotten.

Feb 2022: Beijing Olympics. Ukraine invasion begins. World changed again. I'm still here.

February 2022
✨

Five Years NED

I asked: "What's the protocol now?" He said: "We don't know. You're the only wide-metastasis SCLC patient who's made it this far."

💫
"For some reason I was spared.
God isn't done with me yet.

I think one of the reasons is to help others."
Part Two
🔬

From One Life Saved…
to Understanding Why

What saved my life wasn't luck. It was biology — exploited unintentionally at first, then understood.

When we understand why something works, we can turn discovery into strategy.

The Core Insight

Cancer Is Not Passive
Cancer wants to win.

It adapts. It reroutes. It exploits redundancy.

Treating cancer is like playing American football against yourself:

  • Every weakness gets exploited
  • Every single-point strategy gets countered
  • Every predictable move gets punished

To win, you need a playbook, not a trick.

C FUEL GROW HIDE Proliferation Metabolism Immune Evasion
Joe's Science

Microtubules: Central to Cell Life & Death

  • Intracellular Trafficking — highways for proteins & organelles
  • Cell Shape & Polarity — structural integrity
  • Cell Signaling — communication pathways
  • Mitosis — a proven cancer target

Cancer cells depend on intact microtubules to divide and survive.

NUCLEUS Microtubule network with cargo trafficking
Clinical Reality

Microtubule-Targeting Agents: The Challenge

Proven Goal: MTAs bind tubulin and disrupt cell division.

Critical Challenges:

  • Drug resistance limits efficacy
  • Toxicity harms normal cells
  • Aggressive disruption backfires

We didn't need stronger. We needed smarter.

CLASSIC MTAs Shattered — all cells harmed FENBENDAZOLE p53 ↑ Selective disruption VS
Joe's Science

FZ: A Moderate but Smart MTA

  • Mitotic Arrest — cell cycle interruption
  • Milder Disruption — no classic resistance or toxicity
  • p53 Activation — master tumor suppressor engaged

FZ combines moderate disruption with powerful p53 stabilization.

p53 ACTIVATED p53↑ Centrosome Centrosome MITOTIC ARREST Destabilized just enough to force a mistake
Joe's Science

FZ as a Proteasomal Interferer

Mechanism:

  • Blocks proteasome selectively in cancer cells
  • Commits cells to death, not polyploidy

Clinical Parallel: Similar to bortezomib (FDA-approved).

This is not fringe biology.

BLOCKED Ub Ub Ub Proteins piling up BORTEZOMIB FDA Approved Same mechanism ≈ Proteasome jammed — cancer can't recycle
Joe's Science

Cancer's Addiction: Glucose & Glycolysis

  • Warburg Effect — dramatic glucose overuse
  • Key Drivers — GLUT transporters + Hexokinase II
  • Inflexibility — normal cells adapt, cancer can't

This is cancer's fuel dependency.

CANCER CELL Glucose-dependent NORMAL CELL Metabolically flexible HIGH LOW Glucose Uptake Comparison
Joe's Science

FZ Cuts the Fuel Line

  • GLUT-4 Suppression — transporters shut down
  • HK II Inhibition — hexokinase blocked
  • ATP Depletion — energy crisis

"FZ doesn't just stall mitosis — it cuts the energy supply."

ATP ⚠ ENERGY CRISIS FAILING STOP GLUT-4 ↓ HK II ↓ ATP ↓↓↓ DEATH Energy crisis → Selective cell death
Keystone Insight

p53 Is Not Just a DNA Guardian —
It's a Metabolic Switch

FZ → Tubulin Depolymerization → p53 Upregulation

p53 ACTIVATED TIGAR Glycolysis/PPP SCO2 OXPHOS GLS2 Glutamine PRODH Proline

This links structure → metabolism → fate. p53 isn't just a guardian — FZ flips the switch.

Three Hits, One Outcome

Triple Mechanism of FZ Action

Cancer can't adapt to simultaneous disruption of division, metabolism, and energy.

1

Mitotic Arrest

Microtubule disruption stops division

2

p53 Stabilization

Metabolic reprogramming activated

3

Glucose Blockade

Energy crisis cuts fuel supply

COLLAPSE

Selective cancer death through multi-targeted disruption

The Strategic Pivot

Why This Matters Beyond Me

Fenbendazole exposed something critical:

Cancer survival is modular and domain-based.

It survives by:

  • Switching fuels
  • Bypassing death pathways
  • Hiding from immunity
  • Preserving stem-like escape cells

We fight cancer on its own terms — metabolically.

C FUEL SWITCH DEATH BYPASS IMMUNE HIDE AUDIBLE! Cancer calling audibles across survival domains
The Map Forward

FZ Covers Key Domains —
But Not All

It hits:

  • Division (microtubule disruption)
  • p53 / Apoptosis pathways
  • Glucose metabolism

It does not fully address:

  • Inflammation / immune evasion
  • Stemness / differentiation escape

That's not a failure. That's a map.

DIVISION ✓ p53 ✓ GLUCOSE ✓ IMMUNE EVASION ✗ STEMNESS ✗

"Fenbendazole showed us where cancer is vulnerable.
Pathway 1™, 2™, 3™ & 4™ are how we finish the game."

Part Three
🧪

The Pathway Products

But Fenbendazole wasn't my only change…
I discovered a system that addresses every cellular pathway derangement that cancer exploits.

Pathway 1™, 2™, 3™, and 4™ — each targeting the specific signaling breakdowns that keep cancer alive.

The Curcumin Paradox

Curcumin Is Powerful
…But Nearly Invisible

Curcumin's therapeutic potential is extraordinary:

  • Anti-carcinogenic
  • Anti-inflammatory (NF-κB inhibition)
  • Pro-apoptotic (p53 support)
  • Multi-pathway targeting

The problem?

8 grams of raw curcumin produces only ~50 ng/mL in plasma.

Most curcumin you swallow never reaches your cells.

8,000 mg RAW CURCUMIN ~99% LOST Poor absorption Fast metabolism BLOODSTREAM 50 ng/mL detected Barely therapeutic
ProtiSorb™ Protein Delivery Technology

Same Curcumin.
5.7× Better Delivery.

ProtiSorb™ exploits the observation that once solubilized, polyphenols like curcumin exhibit a higher affinity for binding to proteins rather than self-aggregating — forming a polyphenol-protein complex that promotes rapid, high absorption.

Theracurmin®
31.8
ng·hr/mL
UltraCur®
180
ng·hr/mL

AUC (Area Under Curve) = total exposure over time.

5.67× greater bioavailability means 5.67× more curcumin actually working.

AUC Comparison (Same Curcumin Dose) Time (hours) Plasma (ng/mL) 48 163 Theracurmin® UltraCur® (ProtiSorb™) 5.7× BETTER AUC
Human Evidence

In Humans:
The Numbers Speak

Human observational studies confirmed the advantage:

610

ng/mL per capsule

Average Cmax

139×

vs raw curcumin

Capsule equivalents

Just 30 mg of ProtiSorb™ curcumin achieved plasma levels of 1,400–2,700 ng/mL within 20–50 minutes.

This changes everything about practical dosing.

Capsule Equivalents Comparison (ng/mL per #00 capsule) Raw 4.4 Theracurmin® 54 ProtiSorb™ 610 12× 11× 139× vs Raw
The Strategic Reason

Why I Switched:
It's Not About the Molecule

A compound that can't reach the target is like a playbook no one can read.

💊

Theracurmin®

Good reputation

But limited delivery

That was the old protocol…

→
🎯

ProtiSorb™

Same curcumin

5.7× better delivery

ProtiSorb™ is the patented protein delivery IP powering every Onco-Adjunct™ Pathway product — Pathway 1™, 2™, 3™, and 4™.

The Onco-Adjunct™ Pathways System

Four Pathways. Four Fronts.
One Coordinated Strategy.

Each Pathway targets specific cellular pathway derangements dysregulated in cancer — powered by patented ProtiSorb™ protein delivery technology. Joe recommends all four.

Pathway 1
Pathway 1™
Pathway 2
Pathway 2™
Pathway 3
Pathway 3™
Pathway 4
Pathway 4™
PATHWAY 1™

Epigenetic Signaling

Cannabinoids • Frankincense
Fullerene C60

Overcomes localized epigenetic responses, restoring the cancer microenvironment toward homeostasis. Modulates NF-κB, COX-2, and Wnt/β-catenin signaling.

PATHWAY 2™

Proliferation & Inflammation

ProtiSorb™ Curcumin • Quercetin
Boswellic Acids

NF-κB ⬤9 COX-2 ⬤10 PI3K/mTOR ⬤8
Suppresses tumor inflammation and proliferation dysregulation via PI3K/AKT/mTOR axis.

PATHWAY 3™

AMPK / Energetics

ProtiSorb™ Berberine
Fermented Wheat Germ Extract

AMPK ⬤9–10 mTOR ⬤8–9 Nrf2 ⬤8–9
Disrupts altered energy metabolism. 3™ Plus halts or impedes aerobic glycolysis.

PATHWAY 4™

Apoptosis / Stemness

ProtiSorb™ EGCG • Fisetin
Resveratrol • Beta Glucans

SIRT1 ⬤7–8 EGFR ⬤7–8 p53 ⬤7–8
Restores apoptosis, disrupts stemness, and targets differentiation escape pathways.

The Framework

The Five Pillars of Cancer Survival

Every cancer exploits these five domains. A complete strategy must address all of them.

📈

PROLIFERATION

PI3K/AKT/mTOR
MAPK/ERK • KRAS
BRAF • Wnt/β-catenin
VEGF • TGF-β

💀

APOPTOSIS

p53 • JAK/STAT
FoxO • BRAF

🛡️

INFLAMMATION

NF-κB • COX-2
5-LOX • Nrf2
HIF-1α

⚡

METABOLISM

AMPK • mTOR
VHL-HIF

🧬

STEMNESS

EGFR • SIRT1

Fenbendazole addresses ~3 pillars strongly. Pathway 1™, 2™, 3™, and 4™ complete every domain.

Coverage Analysis

FZ + All Four Pathways =
Complete Coverage

Fenbendazole strengths:

  • Microtubule disruption → Division
  • p53 stabilization → Apoptosis
  • GLUT4 inhibition → Glucose metabolism

Each Pathway fills specific gaps:

  • Pathway 1™ — Cannabinoids, Frankincense, Fullerene → Epigenetic homeostasis, NF-κB, Wnt/β-catenin
  • Pathway 2™ — Curcumin (NF-κB:9, COX-2:10), Quercetin (AMPK:9), Boswellic Acids (5-LOX:9)
  • Pathway 3™ — Berberine (AMPK:9, mTOR:8) + Fermented Wheat Germ (AMPK:10); 3™ Plus impedes glycolysis
  • Pathway 4™ — EGCG, Fisetin (SIRT1:8), Resveratrol (SIRT1:8), Beta Glucans → Apoptosis, stemness, differentiation

Together: All five pillars covered, with synergistic reinforcement across every cancer survival domain.

Five Pillar Coverage Map PROLIF APOP INFLAM METAB STEM FZ ●●● ●●● ● ●● ● P1™ ●●● ●●● ●●●● ●●● ●● P2™ ●●● ●●● ●●●● ●●● ●● P3™ ●●● ●●● ●●● ●●●● ●● P4™ ●●● ●●● ●●● ●●● ●●● ALL FULL FULL FULL FULL FULL Strong Moderate Weak
Synergy Example

Pathway 2™: The Inflammation & Proliferation Assault

Three ProtiSorb™ compounds converging on overlapping proliferation & inflammation pathways:

ProtiSorb™ Curcumin

NF-κB: 9

COX-2: 10

Nrf2: 10

PI3K/mTOR: 8

Inhibits Akt phosphorylation, suppresses VEGF transcription, downregulates HIF-1α

ProtiSorb™ Quercetin

NF-κB: 8

COX-2: 9

Nrf2: 9

AMPK: 9

Suppresses PI3K/Akt/mTOR cascade, activates caspase-driven apoptosis, SIRT1 modulation

Boswellic Acids

NF-κB: 8

COX-2: 9

5-LOX: 9

Wnt/β-cat: 9

Potent 5-LOX inhibitor reducing leukotriene production, blocks inflammation-driven growth

NF-κB is the master switch for tumor inflammation and immune evasion — all three Pathway 2™ compounds converge on it with reinforcing intensity, scoring 8–9 across the board.

Pathway 2™ Triple Synergy Map Curcumin ProtiSorb™ Quercetin ProtiSorb™ Boswellic Acids NF-κB Master Switch 3× SYNERGY COX-2 PI3K/mTOR 5-LOX ● Curcumin 9-10 ● Boswellic 8-9 ● Quercetin 8-9
The Complete Picture

FZ + Pathway 1™, 2™, 3™ & 4™ =
A Real Strategy

Not a trick. Not luck. A coordinated multi-domain assault on the cellular pathway derangements cancer exploits.

P1
P2
P3
P4
🎯

Fenbendazole

Division • p53 • Glucose

🧬

Pathway 1™

Epigenetics • Homeostasis

🔥

Pathway 2™

PI3K/AKT/mTOR • NF-κB

⚡

Pathway 3™

AMPK • Glycolysis Block

💀

Pathway 4™

Apoptosis • Proliferation • Stemness

📊

Heatmap Precision

All 5 Pillars Covered

This is why I changed. ProtiSorb™ delivers the compounds. Pathway 1™, 2™, 3™ & 4™ fill every gap. The Heatmaps guide the strategy.

What's Next

From Understanding
to Application

The science matters. But so does the practice.

P1
P1™
P2
P2™
P3
P3™
P4
P4™
✓ ProtiSorb™ bioavailability solved
✓ 4 Pathways — synergies mapped
✓ Five Pillars fully covered

"When we understand why something works, we can turn discovery into strategy."

— Joe Tippens

ultrabotanica.com

🎗️
"For some reason I was spared.
God isn't done with me yet.

I think one of the reasons is to help others."

Thank you for listening to my journey.

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